ANALYTICAL METHODS FOR SIMULTANEOUS DETERMINATION OF DOLUTEGRAVIR AND LAMIVUDINE IN FIXED‑DOSE COMBINATION FORMULATIONS: A CRITICAL REVIEW

Authors

  • Purohit Priti*, Patel Mitansia Department of Pharmaceutical Chemistry, K.B. Institute of Pharmaceutical Education and Research, A constituent college of Kadi Sarva Vishwavidyalaya, Sector-23, Gandhinagar, Gujarat, India

Keywords:

Dolutegravir, Lamivudine, RP‑HPLC, UPLC, Stability‑indicating, Validation, Fixed‑dose combination

Abstract

The fixed‑dose combination of dolutegravir (DTG) and lamivudine (3TC) requires robust and reproducible analytical methods for analysis and stability testing. This review aims recent literature on simultaneous assay methods, with emphasis on stability‑indicating reversed‑phase liquid chromatography (HPLC/UHPLC/UPLC) and also summarizing spectrophotometric and HPTLC alternatives. A comparative table summarizes chromatographic conditions, validation parameters and practical considerations. We discuss method strengths, limitations, and recommend priorities for impurity profiling and greener workflows.

Published

2025-12-27
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How to Cite

ANALYTICAL METHODS FOR SIMULTANEOUS DETERMINATION OF DOLUTEGRAVIR AND LAMIVUDINE IN FIXED‑DOSE COMBINATION FORMULATIONS: A CRITICAL REVIEW. (2025). KSV Journal of Pharmacy and Health Sciences, 2(2), 1-3. https://ksvjphs.com/index.php/journal/article/view/30

Issue

Volume 2, Issue 2 [July 2025 to December 2025]

Section

Research Articles

Copyright (c) 2025 Purohit Priti*, Patel Mitansia (Author)

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

ANALYTICAL METHODS FOR SIMULTANEOUS DETERMINATION OF DOLUTEGRAVIR AND LAMIVUDINE IN FIXED‑DOSE COMBINATION FORMULATIONS: A CRITICAL REVIEW. (2025). KSV Journal of Pharmacy and Health Sciences, 2(2), 1-3. https://ksvjphs.com/index.php/journal/article/view/30