EFFECT OF MAGNESIUM AND HYDROXYPROPYL METHYLCELLULOSE CO-SUPPLEMENTATION WITH HIGH FAT DIET IN WEIGHT MANAGEMENT IN OBESITY IN RATS

Abstract

Objective: The present study was done to evaluate the effect of Magnesium and Hydroxypropyl Methyl Cellulose (HPMC) co-supplementation along with a high-fat diet (HFD) on metabolic parameters associated with obesity.

 Materials and Methods: Male Albino Wistar rats were divided into five groups each containing 6 animals. All the animals except normal control group I were fed a high-fat diet for 84 days. All the treatment groups received treatment from day 1 itself. Group III was given Magnesium gluconate (containing 58.33 mg elemental magnesium/kg, p.o) along with HFD for 84 days. Group IV was fed with 8% HPMC mixed with HFD for 84 days. Group V was given Magnesium gluconate (containing 58.33 mg elemental magnesium/kg, p.o) + 8% HPMC (mixed with HFD) for 84 days. During the experiment, food intake and were measured weekly and BMI was measured on day 0 and 84. Serum total cholesterol, triglyceride, LDL, HDL, and magnesium levels were measured at days 0, 42, and 84. Fecal stool analysis was done on days 83 and 84, while fat mass was measured at the end of the study.

Results: Co-supplementation of Magnesium and HPMC with HFD significantly reduced body weight, BMI, triglyceride, total cholesterol, LDL, and fat mass, with a significant decrease in food intake. Moreover, a significant increase in the fecal excretion of total bile acids and fatty acids was observed.

Conclusion: The above results suggest that co-supplementation of Magnesium and HPMC not only reduces body weight but also normalizes the metabolic abnormalities associated with obesity and possesses potential fat-reducing and lipid-lowering effects.