PREPARATION AND EVALUATION OF KUMKUMADI OIL LOADED TOPICAL MICROEMULSION
Keywords:
Microemulsion, Kumkumadi oil, Skin whiteningAbstract
Skin whitening is the use of substances, mixtures, or physical treatments to lighten skin color. Sometimes, the terms "lightening", "brightening", "depigmentation" and "bleaching" are also used. In such type of products skin whitening agents are widely used. The present study was conducted for preparation and evaluation of Kumkumadi oil loaded topical microemulsion for skin whitening. Microemulsions (ME) are isotropic, thermodynamically stable, transparent (or translucent) systems of oil, water and surfactant, frequently in combination with a co-surfactant with a droplet size usually in the range of 10-100nm.The optimum concentration of Kumkumadi oil, turmerone and surfactant PEG 200 tri isostearate were obtained using Pseudo Turnery Phase Diagram performed by design of Chemix® software. The final preparations of oil phase were prepared using mixture of Kumkumadi oil 2% v/v and Turmerone 1% v/v, PEG 200 tri isostearate 30% v/v and IPA 20% v/v and water phase consisting of water 47% v/v. The system was evaluated for Dilution Test, Dye solubility Test, Zeta potential, Globule size determination, FTIR study, Electric conductivity, Measurement of pH, Percentage transmittance, Drug precipitation assessment, Microbial limit test, Microbial bio-burden, Poly dispersity index, Stability study at room temperature for 1 Month. The optimized microemulsion having Zeta potential-19.24, Percentage transmittance-99-99.99%, PDI-0.064 and it was found that the formulation was stable for 1 month.
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Copyright (c) 2023 Punit Parejiya, Swapnil Mehta, Het Solanki, Hetal Patel (Author)
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